>Coenzyme Q10 (ubiquinone) is a naturally occurring compound widely
>distributed in animals and humans. The primary compounds
>involved in ubiquinone biosynthesis are 4-hydroxybenzoate and THE
>polyprenyl chain. An essential role of coenzyme Q10 is an
>electron carrier in THE mitochondrial respiratory chain. Moreover,
>coenzyme Q10 is one of the most important lipophilic antioxidantS that
>prevents generation of free radicals as well as oxidative
>modification of proteins, lipids and DNA and can also
>regenerate the other powerful lipophilic antioxidant - a-tocopherol.
>Antioxidant action is the property of the reduced form of coenzyme Q10 -
>ubiquinol (CoQ10H2) and the ubisemiquinone radical (CoQ10H˙).
>Paradoxically, independently of the known antioxidant properties of
>coenzyme Q10, the ubisemiquinone radical anion (CoQ10-˙) possesses
>prooxidative properties. Decreased levels of coenzyme Q10 in humans are observed in many pathologies (e.g. cardiac disorders,
>neurodegenerative diseases, AIDS, cancer) associated with intensive generation of free radicals and their action on cells and tissues. In these cases, treatment involves pharmaceutical supplementation or increased consumption of coenzyme Q10 with meals as well as treatment with adequate chemical compounds (i.e. folic acid or B-group vitamins) which significantly increase ubiquinone biosynthesis in the body. Estimation of coenzyme Q10 deficiency and efficiency of its supplementation requires determination of ubiquinone levels in the body. Therefore, highly selective and sensitive methods must be applied, such as HPLC with UV or colourometry.
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