The study was conducted on isolated, perforated tail arteries of rats. Rated dependency of the effect of the agonist concentration to phenylephrine with indomeatcyną and endothelin-1 with indomethacin and compared with the results of administration of the agonist. The study was conducted on the arteries of normal and without endothelium. Additionally determined perfusion pressure associated with the influx into the cell cytoplasm of ions calcium intra- and extracellular.